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Open Biol (2019) 9(7):190099

Furthermore, FXR activation regulates intestinal immune cells, particularly innate ILCs, suppresses the expression of pro-inflammatory cytokines, and modulates immune homeostasis [473]

Previous studies on bone metabolism reported that phytoestrogens, including icariin and ginsenoside Rg1, influence the function of bone cells by activating GPER